Vicodin (a hydrocodone/paracetamol combination), also known as, hydrocodone, or under brands such as Lortab, Norco, or Vicodin, is a combination narcotic pain reliever consisting of hydrocodone and paracetamol. The drug is used to relieve moderate to severe pain. Vicodin for sale is easily accessible and can be bought at medical stores with doctor’s prescriptions in the US. You can also order Vicodin online.
Pharmaceutical group: analgesics; combined analgesics based on paracetamol and opioids. Action receptors: mu-opioid receptors Active ingredient: hydrocodone and opioid analgesics, paracetamol, and anilide pain relievers. Trade names: Lortab, Norco, Vicodin, and many others.
Formulas
The hydrocodone/paracetamol combination is a two-ingredient narcotic analgesic formula consisting of the narcotic analgesic hydrocodone and paracetamol.
Medical Uses of Vicodin
Vicodin is indicated to relieve moderate to moderately severe acute, chronic, or postoperative pain.
Side effects of Vicodin
Common side effects of narcotic analgesics include nausea, vomiting, constipation, and dry mouth. Non-medical use of Vicodin In recent years, the abuse of hydrocodone has escalated. In 2009 and 2010, hydrocodone was the second most commonly found opioid pharmaceutical based on data provided by US federal, state, and local forensic laboratories, as reported by the DEA National Forensic Laboratory Information System and Trafficking Information System. Vicodin Market In 2007, 99% of hydrocodone was consumed in the United States. In 2012, hydrocodone was the most commonly prescribed opiate in the United States. In the United States, 142 million prescriptions have been issued for products containing the hydrocodone combination, with the hydrocodone/acetaminophen combination being the most common.
Pharmacodynamics Hydrocodone
Hydrocodone acts on mu-opioid receptors. Hydrocodone is metabolized to hydromorphone via the activity of cytochrome P450 2D6. Cytochrome 3A4 forms the substrate nordihydrocodone. It should be noted that this transformation is only to some extent responsible for the effects of hydrocodone. Hydrocodone crosses the blood-brain barrier (BBB) due to its modifications. In the brain, as a rule, the analgesic effect of the drug is carried out. Many of the side effects of this drug are because it crosses the blood-brain barrier so easily. The half-life of hydrocodone is approximately 3.8 hours.
Paracetamol: the primary active metabolites are sulfates and glucuronide conjugates. The main mechanism of action is inhibition of the activity of the enzyme cyclooxygenase (COX). COX enzymes are essential for the production of prostaglandins. Prostaglandins are a form of hormone (although they are rarely classified as such) indicated as mediators of pain, fever, and inflammation. The half-life of paracetamol can be measured using saliva or plasma tests. The half-life can be from 1 to 4 hours. Maximum levels are reached 40-60 minutes after ingestion. It has been suggested that paracetamol helps in reducing pain by increasing serotonergic neurotransmission.
Vicodin Production
The opioid moiety hydrocodone has the same basic structure as morphine but is metabolized by various enzymes. Hydrocodone, like oxycodone, is a moderate-strength analgesic with the same effects as morphine; with short-term oral administration, hydrocodone is approximately twice as active as morphine. The mixture theory is based on the idea that these drugs relieve pain through different mechanisms and that when the dosage of both drugs is reduced, the adverse side effects of each drug are reduced, providing the same pain relief.
